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Isometamidium powder for injection


Contains per sachet:
Isometamidium chloride hydrochloride  1000 mg
Antiprine                            5200 mg
Isometamidium is a phenanthridine aromatic amidine with a narrow therapeutic index which has been marketed for over 30 years as both a prophylactic and a therapeutic trypanocidal agent in the field. Isometamidium chloride is used curatively at lower dosage rates, and prophylactically at higher dosage rates.
Intromidium is indicated for treatment and prevention of trypanosomiasis caused by Trypanosoma spp. in cattle, goats, sheep, camels, horses and dogs. Preventive dosage ensures protection for 2 to 4 months. When clinical cases occur, the whole group should be treated.
Contra indications:
Intromidium should not be administered subcutaneously.
Avoid concurrent administration of other trypanocidal drugs, particularly diminazene aceturate.
Avoid underdosing.
Side effects:
Individual sensitivity to Intromidium is possible.
For parenteral administration. Dissolve the content of one sachet of Intromidium in 50 ml or 100 ml of sterile water for injection to obtain a 2% or a 1% solution, respectively. Repeated injections are needed at intervals of 10 to 12 weeks or more, depending on the level of fly challenge.
Calves, goats and sheep: treatment: 0.25 -0.5 mg/kg by deep IM injection.
               : prevention: 0.5 -1 mg/kg by deep IM injection.
Camels: 0.5 -0.75 mg/kg using a 1% solution by very slow IV injection.
Horses: 0.5 mg/kg by deep IM injection.
Dogs: 1 mg/kg by deep IM injection.
Deep IM injection should occur preferably in the middle third of the neck in large animals. Doses exceeding 10 ml should be injected at multiple injection sites on each side of the neck. Make sure that the syringe is completely empty before retracting it from the IM injection site. Afterwards, to prevent leakage of Intromidium into subcutaneous tissues, firm pressure must be applied on the injection site. Sheep and goats are injected deep in their thigh muscles.
Withdrawal times:
- For meat: 30 days.
- For milk: 0 days.
Keep out of reach of children.
3 years
Protect from light and store in a cool dry place and below 30ºC.

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